Drug interactions
Deutetrabenazine + Salbutamol
Severity: Moderate
Deutetrabenazine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salbutamol can prolong the QT interval and cause hypokalemia, and deutetrabenazine may add a small QT effect at higher exposures. The combined risk of torsades de pointes is mainly relevant in patients with other risk factors.
What this interaction means in plain words
Deutetrabenazine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Additive pharmacodynamic QT prolongation, with salbutamol-induced hypokalemia and tachycardia further increasing arrhythmic susceptibility.
What to do
Check baseline ECG and electrolytes in patients with QT risk factors, and correct potassium and magnesium. Monitor ECG if salbutamol is used at high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Salbutamol?
MediHelp rates the interaction as moderate. Deutetrabenazine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salbutamol can prolong the QT interval and cause hypokalemia, and deutetrabenazine may add a small QT effect at higher exposures. The combined risk of torsades de pointes is mainly relevant in patients with other risk factors.
How serious is the interaction between Deutetrabenazine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with QT risk factors, and correct potassium and magnesium. Monitor ECG if salbutamol is used at high doses.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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