Drug interactions
Deutetrabenazine + Salmeterol
Severity: Moderate
Deutetrabenazine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can prolong the QT interval, particularly at high doses or with hypokalemia. Deutetrabenazine has little QT effect at recommended doses but may add to the risk in susceptible patients.
What this interaction means in plain words
Deutetrabenazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization, with salmeterol-related hypokalemia as a further contributor.
What to do
Check baseline ECG and electrolytes in patients with risk factors such as bradycardia, electrolyte disturbance or congenital long QT. Correct potassium and magnesium abnormalities and avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Salmeterol?
MediHelp rates the interaction as moderate. Deutetrabenazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol can prolong the QT interval, particularly at high doses or with hypokalemia. Deutetrabenazine has little QT effect at recommended doses but may add to the risk in susceptible patients.
How serious is the interaction between Deutetrabenazine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with risk factors such as bradycardia, electrolyte disturbance or congenital long QT. Correct potassium and magnesium abnormalities and avoid adding further QT-prolonging drugs.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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