Drug interactions
Devil's claw + Piroxicam
Severity: Minor
Devil's claw and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw has been reported to have antiplatelet activity and may add to the bleeding tendency already present with piroxicam. Clinical evidence is limited and mostly theoretical or from isolated reports.
What this interaction means in plain words
Devil's claw and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive impairment of platelet function; piroxicam inhibits platelet COX-1 while devil's claw may have a weak antiplatelet effect.
What to do
Ask patients about herbal use and advise reporting bruising or bleeding. Consider avoiding the herb if the patient also takes anticoagulants or has a high bleeding risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Devil's claw with Piroxicam?
MediHelp rates the interaction as minor. Devil's claw and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Devil's claw has been reported to have antiplatelet activity and may add to the bleeding tendency already present with piroxicam. Clinical evidence is limited and mostly theoretical or from isolated reports.
How serious is the interaction between Devil's claw and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise reporting bruising or bleeding. Consider avoiding the herb if the patient also takes anticoagulants or has a high bleeding risk.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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