Drug interactions
Dexamethasone + Felodipine
Severity: Moderate
Dexamethasone and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and can lower felodipine concentrations, potentially weakening its antihypertensive effect. Sodium retention from corticosteroids may further raise blood pressure.
What this interaction means in plain words
Dexamethasone and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Felodipine belongs to Cardiovascular.
Why it happens
Dexamethasone induces CYP3A4, increasing felodipine first-pass and systemic metabolism.
What to do
Monitor blood pressure during prolonged dexamethasone courses and titrate felodipine upward if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Felodipine?
MediHelp rates the interaction as moderate. Dexamethasone and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone is a CYP3A4 inducer and can lower felodipine concentrations, potentially weakening its antihypertensive effect. Sodium retention from corticosteroids may further raise blood pressure.
How serious is the interaction between Dexamethasone and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged dexamethasone courses and titrate felodipine upward if needed.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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