Drug interactions
Dexamethasone + Fosinopril-hydrochlorothiazide
Severity: Moderate
Dexamethasone and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone and hydrochlorothiazide can both lower serum potassium, so hypokalemia may be additive, and glucocorticoids may also counteract antihypertensive effects through fluid retention and blood glucose may rise. This matters more with prolonged or high-dose therapy.
What this interaction means in plain words
Dexamethasone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting; corticosteroid-related sodium retention opposes the antihypertensive effect.
What to do
Monitor serum potassium and blood pressure during combined use and replace potassium as needed. Check glucose in diabetic patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dexamethasone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone and hydrochlorothiazide can both lower serum potassium, so hypokalemia may be additive, and glucocorticoids may also counteract antihypertensive effects through fluid retention and blood glucose may rise. This matters more with prolonged or high-dose therapy.
How serious is the interaction between Dexamethasone and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during combined use and replace potassium as needed. Check glucose in diabetic patients.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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