Drug interactions
Dexamethasone + Isavuconazonium
Severity: Moderate
Dexamethasone and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may lower isavuconazole concentrations through CYP3A4 induction, risking reduced antifungal efficacy. Corticosteroid immunosuppression also raises fungal infection risk.
What this interaction means in plain words
Dexamethasone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Isavuconazonium belongs to Anti Fungals.
Why it happens
Dexamethasone induces CYP3A4, increasing isavuconazole clearance, and adds immunosuppression.
What to do
Monitor clinical response to antifungal therapy and consider isavuconazole levels if available; use the lowest effective steroid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Dexamethasone with Isavuconazonium?
MediHelp rates the interaction as moderate. Dexamethasone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may lower isavuconazole concentrations through CYP3A4 induction, risking reduced antifungal efficacy. Corticosteroid immunosuppression also raises fungal infection risk.
How serious is the interaction between Dexamethasone and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy and consider isavuconazole levels if available; use the lowest effective steroid dose.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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