Drug interactions
Dexamethasone + Oxaprozin
Severity: Moderate
Dexamethasone and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic dexamethasone with an NSAID increases the likelihood of gastric ulceration and gastrointestinal bleeding. The risk is greater with high doses, prolonged courses and older age.
What this interaction means in plain words
Dexamethasone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID suppression of gastroprotective prostaglandins plus corticosteroid impairment of mucosal repair gives additive ulcerogenic effects.
What to do
Limit the duration of combined use and add a proton pump inhibitor in higher-risk patients. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Oxaprozin?
MediHelp rates the interaction as moderate. Dexamethasone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic dexamethasone with an NSAID increases the likelihood of gastric ulceration and gastrointestinal bleeding. The risk is greater with high doses, prolonged courses and older age.
How serious is the interaction between Dexamethasone and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of combined use and add a proton pump inhibitor in higher-risk patients. Monitor for signs of GI bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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