Drug interactions
Dexamethasone + Quinidine
Severity: Minor
Dexamethasone and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein, which may slightly raise dexamethasone exposure. The clinical effect is expected to be small.
What this interaction means in plain words
Dexamethasone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein efflux of dexamethasone.
What to do
No dose change is usually required. Watch for exaggerated corticosteroid effects with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Quinidine?
MediHelp rates the interaction as minor. Dexamethasone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits P-glycoprotein, which may slightly raise dexamethasone exposure. The clinical effect is expected to be small.
How serious is the interaction between Dexamethasone and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Watch for exaggerated corticosteroid effects with prolonged use.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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