Drug interactions
Dexamethasone + Riociguat
Severity: Minor
Dexamethasone and Riociguat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a weak to moderate CYP3A4 inducer and could lower riociguat exposure, reducing its effect on pulmonary hypertension. The magnitude has not been well characterized.
What this interaction means in plain words
Dexamethasone and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Riociguat belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by dexamethasone may increase riociguat metabolism.
What to do
Monitor clinical response and blood pressure, and adjust the riociguat dose as needed if dexamethasone is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Dexamethasone with Riociguat?
MediHelp rates the interaction as minor. Dexamethasone and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a weak to moderate CYP3A4 inducer and could lower riociguat exposure, reducing its effect on pulmonary hypertension. The magnitude has not been well characterized.
How serious is the interaction between Dexamethasone and Riociguat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood pressure, and adjust the riociguat dose as needed if dexamethasone is used long term.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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