Drug interactions
Dexamethasone + Vinblastine
Severity: Minor
Dexamethasone and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a weak to moderate CYP3A4 inducer and may modestly lower exposure to vinblastine, a CYP3A4 substrate. The clinical consequence is uncertain and is generally small, particularly because dexamethasone is often used within chemotherapy regimens.
What this interaction means in plain words
Dexamethasone and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Vinblastine belongs to Oncology.
Why it happens
Induction of CYP3A4 by dexamethasone may increase the metabolism of vinblastine.
What to do
No routine change is needed; monitor for reduced antineoplastic response and vinblastine toxicity according to the protocol in use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Dexamethasone with Vinblastine?
MediHelp rates the interaction as minor. Dexamethasone and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a weak to moderate CYP3A4 inducer and may modestly lower exposure to vinblastine, a CYP3A4 substrate. The clinical consequence is uncertain and is generally small, particularly because dexamethasone is often used within chemotherapy regimens.
How serious is the interaction between Dexamethasone and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for reduced antineoplastic response and vinblastine toxicity according to the protocol in use.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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