Drug interactions
Dexamethasone + Zafirlukast
Severity: Minor
Dexamethasone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 substrate, so inhibitors may slightly raise its exposure. With zafirlukast's weak inhibition, the effect is unlikely to be clinically important.
What this interaction means in plain words
Dexamethasone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may slightly reduce dexamethasone metabolism.
What to do
No dose change is required. Monitor for corticosteroid adverse effects such as hyperglycemia with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Zafirlukast?
MediHelp rates the interaction as minor. Dexamethasone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a CYP3A4 substrate, so inhibitors may slightly raise its exposure. With zafirlukast's weak inhibition, the effect is unlikely to be clinically important.
How serious is the interaction between Dexamethasone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor for corticosteroid adverse effects such as hyperglycemia with prolonged use.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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