Drug interactions
Dexamethasone-neomycin-polymyxin + Duvelisib
Severity: Minor
Dexamethasone-neomycin-polymyxin and Duvelisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as dexamethasone. With topical or ophthalmic dexamethasone, the systemic increase is expected to be small.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing dexamethasone clearance.
What to do
No adjustment is usually needed for topical use; monitor for corticosteroid adverse effects if used for a prolonged period over large areas or systemically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Duvelisib?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duvelisib inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as dexamethasone. With topical or ophthalmic dexamethasone, the systemic increase is expected to be small.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Duvelisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed for topical use; monitor for corticosteroid adverse effects if used for a prolonged period over large areas or systemically.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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