Drug interactions
Dexamethasone-neomycin-polymyxin + Gefitinib
Severity: Minor
Dexamethasone-neomycin-polymyxin and Gefitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and reduce gefitinib exposure, potentially lowering efficacy. With topical or ophthalmic dexamethasone the induction is probably insignificant.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Gefitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Gefitinib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, increasing gefitinib metabolism.
What to do
No adjustment is needed for topical use; with prolonged systemic dexamethasone, monitor tumor response to gefitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Gefitinib
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Gefitinib?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Gefitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and reduce gefitinib exposure, potentially lowering efficacy. With topical or ophthalmic dexamethasone the induction is probably insignificant.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Gefitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed for topical use; with prolonged systemic dexamethasone, monitor tumor response to gefitinib.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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