Drug interactions
Dexamethasone-neomycin-polymyxin + Indomethacin
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the likelihood of gastric irritation, ulceration and bleeding. This applies mainly when the dexamethasone combination is absorbed systemically; with topical ear or eye use the risk is low.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Indomethacin belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury from corticosteroid effects and NSAID inhibition of protective prostaglandins.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for gastroprotection if systemic exposure is expected. Watch for dyspepsia, melena or other signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Indomethacin?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the likelihood of gastric irritation, ulceration and bleeding. This applies mainly when the dexamethasone combination is absorbed systemically; with topical ear or eye use the risk is low.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for gastroprotection if systemic exposure is expected. Watch for dyspepsia, melena or other signs of GI bleeding.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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