Drug interactions
Dexamethasone-neomycin-polymyxin + Isavuconazonium
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may lower isavuconazole concentrations through CYP3A4 induction, risking reduced antifungal efficacy. Corticosteroid immunosuppression also increases infection risk. Isavuconazole may in turn increase dexamethasone exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Isavuconazonium belongs to Anti Fungals.
Why it happens
Dexamethasone induces CYP3A4, while isavuconazole is a moderate CYP3A4 inhibitor.
What to do
Monitor antifungal response and consider isavuconazole levels where available. Monitor for corticosteroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Isavuconazonium?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may lower isavuconazole concentrations through CYP3A4 induction, risking reduced antifungal efficacy. Corticosteroid immunosuppression also increases infection risk. Isavuconazole may in turn increase dexamethasone exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antifungal response and consider isavuconazole levels where available. Monitor for corticosteroid adverse effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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