Drug interactions
Dexamethasone-neomycin-polymyxin + Lenacapavir
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise dexamethasone exposure. Higher levels can cause Cushingoid effects and adrenal suppression with prolonged systemic use. With topical use of this combination product, systemic exposure is small, so the risk is limited.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing dexamethasone metabolism.
What to do
With topical use, short courses are generally acceptable. With prolonged or extensive use, monitor for Cushingoid features and adrenal suppression and use the lowest effective dexamethasone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lenacapavir?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise dexamethasone exposure. Higher levels can cause Cushingoid effects and adrenal suppression with prolonged systemic use. With topical use of this combination product, systemic exposure is small, so the risk is limited.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With topical use, short courses are generally acceptable. With prolonged or extensive use, monitor for Cushingoid features and adrenal suppression and use the lowest effective dexamethasone dose.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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