Drug interactions
Dexamethasone-neomycin-polymyxin + Mitotane
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and substantially lowers dexamethasone exposure. This matters when dexamethasone is used systemically, and mitotane patients also need steroid replacement. Effect with topical use is limited by low systemic exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Mitotane belongs to Oncology.
Why it happens
Mitotane strongly induces CYP3A4, increasing dexamethasone clearance.
What to do
Monitor clinical response to dexamethasone and adjust the dose upward if needed. Note that mitotane patients often need higher glucocorticoid replacement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Mitotane?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and substantially lowers dexamethasone exposure. This matters when dexamethasone is used systemically, and mitotane patients also need steroid replacement. Effect with topical use is limited by low systemic exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dexamethasone and adjust the dose upward if needed. Note that mitotane patients often need higher glucocorticoid replacement.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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