Drug interactions
Dexamethasone-neomycin-polymyxin + Prednisone
Severity: Minor
Dexamethasone-neomycin-polymyxin and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and modestly alter prednisolone exposure, but both are corticosteroids and the combination mainly adds duplicate glucocorticoid effect.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Prednisone belongs to Endocrine.
Why it happens
Duplicate glucocorticoid activity with minor CYP3A4 induction.
What to do
Avoid unnecessary duplication of systemic steroids and monitor glucose and blood pressure if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Prednisone?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and modestly alter prednisolone exposure, but both are corticosteroids and the combination mainly adds duplicate glucocorticoid effect.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of systemic steroids and monitor glucose and blood pressure if used together.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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