Drug interactions
Dexamethasone-neomycin-polymyxin + Quetiapine
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower quetiapine concentrations, potentially reducing psychiatric control. Effect is mainly with systemic steroids.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases quetiapine metabolism.
What to do
Monitor psychiatric response and adjust quetiapine dose if prolonged systemic dexamethasone is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Quetiapine?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce CYP3A4 and lower quetiapine concentrations, potentially reducing psychiatric control. Effect is mainly with systemic steroids.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and adjust quetiapine dose if prolonged systemic dexamethasone is given.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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