Drug interactions
Dexamethasone-neomycin-polymyxin + Riociguat
Severity: Minor
Dexamethasone-neomycin-polymyxin and Riociguat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and modestly lower riociguat exposure. With topical or ophthalmic dexamethasone the effect is likely negligible.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Riociguat belongs to Cardiovascular.
Why it happens
Dexamethasone induces CYP3A4, which contributes to riociguat metabolism.
What to do
No adjustment is needed for topical use; with prolonged systemic dexamethasone, monitor blood pressure and clinical response to riociguat.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Riociguat?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and modestly lower riociguat exposure. With topical or ophthalmic dexamethasone the effect is likely negligible.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Riociguat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed for topical use; with prolonged systemic dexamethasone, monitor blood pressure and clinical response to riociguat.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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