Drug interactions
Dexamethasone-tobramycin + Ethacrynic acid
Severity: Moderate
Dexamethasone-tobramycin and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid and aminoglycosides like tobramycin both can damage the cochlea and kidney, so combined use raises the risk of hearing loss and renal injury. This matters mainly with systemic tobramycin; topical or ophthalmic use gives little exposure.
What this interaction means in plain words
Dexamethasone-tobramycin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuretic-induced volume depletion increasing aminoglycoside toxicity.
What to do
If tobramycin is given systemically, avoid ethacrynic acid where possible, or monitor renal function, tobramycin levels and hearing. No action is needed for topical or ophthalmic tobramycin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Dexamethasone-tobramycin with Ethacrynic acid?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid and aminoglycosides like tobramycin both can damage the cochlea and kidney, so combined use raises the risk of hearing loss and renal injury. This matters mainly with systemic tobramycin; topical or ophthalmic use gives little exposure.
How serious is the interaction between Dexamethasone-tobramycin and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If tobramycin is given systemically, avoid ethacrynic acid where possible, or monitor renal function, tobramycin levels and hearing. No action is needed for topical or ophthalmic tobramycin.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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