Drug interactions
Dexamethasone-tobramycin + Etravirine
Severity: Moderate
Dexamethasone-tobramycin and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine and dexamethasone are both CYP3A4 inducers and may lower each other's concentrations. With systemic dexamethasone this could reduce antiviral efficacy or corticosteroid effect.
What this interaction means in plain words
Dexamethasone-tobramycin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Etravirine belongs to Anti Virals.
Why it happens
Mutual CYP3A4 induction.
What to do
With systemic dexamethasone, monitor HIV viral load and clinical corticosteroid response. Local use rarely needs adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Etravirine?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine and dexamethasone are both CYP3A4 inducers and may lower each other's concentrations. With systemic dexamethasone this could reduce antiviral efficacy or corticosteroid effect.
How serious is the interaction between Dexamethasone-tobramycin and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor HIV viral load and clinical corticosteroid response. Local use rarely needs adjustment.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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