Drug interactions
Dexamethasone-tobramycin + Fosaprepitant
Severity: Moderate
Dexamethasone-tobramycin and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, moderately inhibits CYP3A4 and increases dexamethasone exposure. Antiemetic regimens usually reduce the oral dexamethasone dose for this reason.
What this interaction means in plain words
Dexamethasone-tobramycin and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 inhibition by aprepitant decreases dexamethasone clearance.
What to do
When dexamethasone is given systemically as an antiemetic, reduce its dose as recommended in labeling. No adjustment is needed for local use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Fosaprepitant?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant, the active form of fosaprepitant, moderately inhibits CYP3A4 and increases dexamethasone exposure. Antiemetic regimens usually reduce the oral dexamethasone dose for this reason.
How serious is the interaction between Dexamethasone-tobramycin and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When dexamethasone is given systemically as an antiemetic, reduce its dose as recommended in labeling. No adjustment is needed for local use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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