Drug interactions
Dexamethasone-tobramycin + Gentamicin
Severity: Moderate
Dexamethasone-tobramycin and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic gentamicin and tobramycin are both nephrotoxic and ototoxic, so combining them adds risk. With topical tobramycin in the combination product the systemic exposure is small, but concurrent systemic aminoglycoside therapy warrants caution, especially with extensive or prolonged topical use.
What this interaction means in plain words
Dexamethasone-tobramycin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive aminoglycoside toxicity to renal tubular cells and cochlear hair cells.
What to do
Avoid concurrent systemic and prolonged topical aminoglycosides where possible; if used together, monitor renal function and serum aminoglycoside levels and watch for hearing or balance changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Gentamicin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic gentamicin and tobramycin are both nephrotoxic and ototoxic, so combining them adds risk. With topical tobramycin in the combination product the systemic exposure is small, but concurrent systemic aminoglycoside therapy warrants caution, especially with extensive or prolonged topical use.
How serious is the interaction between Dexamethasone-tobramycin and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic and prolonged topical aminoglycosides where possible; if used together, monitor renal function and serum aminoglycoside levels and watch for hearing or balance changes.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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