Drug interactions
Dexamethasone-tobramycin + Lomitapide
Severity: Minor
Dexamethasone-tobramycin and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and could increase exposure to P-gp substrates such as dexamethasone. The clinical effect is likely small, and with ophthalmic use systemic exposure is negligible. Lomitapide's main concerns are hepatotoxicity and CYP3A4 interactions, not this one.
What this interaction means in plain words
Dexamethasone-tobramycin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Lomitapide belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux by lomitapide, which may raise dexamethasone exposure.
What to do
No routine action is needed. With prolonged systemic dexamethasone, monitor for corticosteroid adverse effects and reduce the dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Lomitapide?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein and could increase exposure to P-gp substrates such as dexamethasone. The clinical effect is likely small, and with ophthalmic use systemic exposure is negligible. Lomitapide's main concerns are hepatotoxicity and CYP3A4 interactions, not this one.
How serious is the interaction between Dexamethasone-tobramycin and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. With prolonged systemic dexamethasone, monitor for corticosteroid adverse effects and reduce the dose if they appear.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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