Drug interactions
Dexamethasone-tobramycin + Magnesium hydroxide
Severity: Minor
Dexamethasone-tobramycin and Magnesium hydroxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides given systemically can cause renal magnesium wasting and hypomagnesemia, which may reduce magnesium status. Oral magnesium hydroxide is mainly an antacid or laxative and the effect is minor, especially with topical tobramycin.
What this interaction means in plain words
Dexamethasone-tobramycin and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Aminoglycoside-induced renal tubular injury increases urinary magnesium loss.
What to do
With systemic tobramycin, monitor serum magnesium and replace if low; no action is needed for topical use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Magnesium hydroxide
Frequently asked questions
Can I take Dexamethasone-tobramycin with Magnesium hydroxide?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminoglycosides given systemically can cause renal magnesium wasting and hypomagnesemia, which may reduce magnesium status. Oral magnesium hydroxide is mainly an antacid or laxative and the effect is minor, especially with topical tobramycin.
How serious is the interaction between Dexamethasone-tobramycin and Magnesium hydroxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic tobramycin, monitor serum magnesium and replace if low; no action is needed for topical use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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