Drug interactions
Dexamethasone-tobramycin + Moxifloxacin
Severity: Moderate
Dexamethasone-tobramycin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones and systemic corticosteroids each raise the risk of tendinopathy, and using them together increases the chance of tendon inflammation or rupture, especially the Achilles tendon. Risk is higher in older patients and those on prolonged steroid courses. With an ophthalmic or otic dexamethasone-tobramycin product, systemic exposure is low and the risk is correspondingly smaller.
What this interaction means in plain words
Dexamethasone-tobramycin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic tendon toxicity from fluoroquinolone-related collagen and tenocyte injury combined with corticosteroid-induced tendon weakening.
What to do
Counsel the patient to stop moxifloxacin and rest the limb if tendon pain or swelling develops. Prefer a non-fluoroquinolone antibiotic in older patients or those on prolonged systemic steroids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Moxifloxacin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones and systemic corticosteroids each raise the risk of tendinopathy, and using them together increases the chance of tendon inflammation or rupture, especially the Achilles tendon. Risk is higher in older patients and those on prolonged steroid courses. With an ophthalmic or otic dexamethasone-tobramycin product, systemic exposure is low and the risk is correspondingly smaller.
How serious is the interaction between Dexamethasone-tobramycin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to stop moxifloxacin and rest the limb if tendon pain or swelling develops. Prefer a non-fluoroquinolone antibiotic in older patients or those on prolonged systemic steroids.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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