Drug interactions
Dexamethasone-tobramycin + Oxaliplatin
Severity: Minor
Dexamethasone-tobramycin and Oxaliplatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides and platinum agents are both nephrotoxic and ototoxic, so systemic exposure to both could add to kidney and hearing injury. With topical dexamethasone-tobramycin, systemic tobramycin exposure is low and the risk is limited.
What this interaction means in plain words
Dexamethasone-tobramycin and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity and ototoxicity of aminoglycoside and platinum compounds, relevant mainly with systemic tobramycin.
What to do
No action for topical use. If systemic tobramycin is given, monitor serum creatinine and hearing and avoid other nephrotoxins where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Oxaliplatin?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aminoglycosides and platinum agents are both nephrotoxic and ototoxic, so systemic exposure to both could add to kidney and hearing injury. With topical dexamethasone-tobramycin, systemic tobramycin exposure is low and the risk is limited.
How serious is the interaction between Dexamethasone-tobramycin and Oxaliplatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action for topical use. If systemic tobramycin is given, monitor serum creatinine and hearing and avoid other nephrotoxins where possible.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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