Drug interactions
Dexamethasone-tobramycin + Ribociclib
Severity: Minor
Dexamethasone-tobramycin and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise dexamethasone exposure. This could increase glucocorticoid effects such as hyperglycemia, fluid retention and immunosuppression, particularly with prolonged use.
What this interaction means in plain words
Dexamethasone-tobramycin and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing dexamethasone clearance.
What to do
Monitor for glucocorticoid adverse effects such as hyperglycemia and fluid retention, and reduce the dexamethasone dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Ribociclib?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate CYP3A4 inhibitor and may raise dexamethasone exposure. This could increase glucocorticoid effects such as hyperglycemia, fluid retention and immunosuppression, particularly with prolonged use.
How serious is the interaction between Dexamethasone-tobramycin and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for glucocorticoid adverse effects such as hyperglycemia and fluid retention, and reduce the dexamethasone dose if they emerge.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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