Drug interactions
Dexamethasone-tobramycin + Saxagliptin
Severity: Minor
Dexamethasone-tobramycin and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and counteract saxagliptin. Dexamethasone may also lower saxagliptin exposure through CYP3A4 induction, though the effect is small.
What this interaction means in plain words
Dexamethasone-tobramycin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Saxagliptin belongs to Endocrine.
Why it happens
Glucocorticoid-induced hyperglycemia opposes saxagliptin, and CYP3A4 induction can increase its metabolism.
What to do
Monitor blood glucose when systemic dexamethasone is used and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Saxagliptin?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids raise blood glucose and counteract saxagliptin. Dexamethasone may also lower saxagliptin exposure through CYP3A4 induction, though the effect is small.
How serious is the interaction between Dexamethasone-tobramycin and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when systemic dexamethasone is used and adjust antidiabetic therapy if needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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