Drug interactions
Dexamethasone-tobramycin + Sirolimus
Severity: Moderate
Dexamethasone-tobramycin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic dexamethasone may lower sirolimus concentrations via CYP3A4 induction, risking reduced immunosuppression. Topical use has minimal systemic effect.
What this interaction means in plain words
Dexamethasone-tobramycin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Sirolimus belongs to Miscellaneous.
Why it happens
Dexamethasone induces CYP3A4 and possibly P-gp, increasing sirolimus clearance.
What to do
With systemic dexamethasone, monitor sirolimus trough levels and adjust the dose. No change is needed for topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Sirolimus?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic dexamethasone may lower sirolimus concentrations via CYP3A4 induction, risking reduced immunosuppression. Topical use has minimal systemic effect.
How serious is the interaction between Dexamethasone-tobramycin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor sirolimus trough levels and adjust the dose. No change is needed for topical use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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