Drug interactions
Dexamethasone-tobramycin + Tipranavir
Severity: Moderate
Dexamethasone-tobramycin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can induce CYP3A4 and may lower tipranavir concentrations, which is relevant because tipranavir is used with ritonavir in resistant HIV. Tipranavir/ritonavir may in turn raise dexamethasone exposure through net CYP3A4 inhibition.
What this interaction means in plain words
Dexamethasone-tobramycin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Tipranavir belongs to Anti Virals.
Why it happens
CYP3A4 induction by dexamethasone may lower tipranavir levels, while the ritonavir-boosted regimen may inhibit dexamethasone metabolism.
What to do
Monitor HIV viral load with prolonged systemic dexamethasone and watch for corticosteroid excess. Limit dexamethasone dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Tipranavir?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone can induce CYP3A4 and may lower tipranavir concentrations, which is relevant because tipranavir is used with ritonavir in resistant HIV. Tipranavir/ritonavir may in turn raise dexamethasone exposure through net CYP3A4 inhibition.
How serious is the interaction between Dexamethasone-tobramycin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load with prolonged systemic dexamethasone and watch for corticosteroid excess. Limit dexamethasone dose and duration.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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