Drug interactions
Dexbrompheniramine + Esketamine
Severity: Moderate
Dexbrompheniramine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexbrompheniramine is a sedating first-generation antihistamine and can add to esketamine sedation, dizziness and impaired cognition.
What this interaction means in plain words
Dexbrompheniramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexbrompheniramine belongs to Respiratory; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Avoid the antihistamine on esketamine treatment days if possible and monitor sedation during post-dose observation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Dexbrompheniramine
- Amisulpride + Dexbrompheniramine Moderate
- Asenapine + Dexbrompheniramine Moderate
- Brexpiprazole + Dexbrompheniramine Moderate
- Brimonidine + Dexbrompheniramine Moderate
- Brivaracetam + Dexbrompheniramine Moderate
- Cariprazine + Dexbrompheniramine Moderate
Frequently asked questions
Can I take Dexbrompheniramine with Esketamine?
MediHelp rates the interaction as moderate. Dexbrompheniramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexbrompheniramine is a sedating first-generation antihistamine and can add to esketamine sedation, dizziness and impaired cognition.
How serious is the interaction between Dexbrompheniramine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the antihistamine on esketamine treatment days if possible and monitor sedation during post-dose observation.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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