Drug interactions
Brimonidine + Dexbrompheniramine
Severity: Moderate
Brimonidine and Dexbrompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexbrompheniramine is a sedating first-generation antihistamine. Together with brimonidine, drowsiness and reduced alertness may be increased.
What this interaction means in plain words
Brimonidine and Dexbrompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Dexbrompheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from central H1 blockade and alpha-2 agonism.
What to do
Advise patients to avoid driving or hazardous tasks if drowsy. Consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brimonidine and Dexbrompheniramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Dexbrompheniramine
- Amisulpride + Dexbrompheniramine Moderate
- Asenapine + Dexbrompheniramine Moderate
- Brexpiprazole + Dexbrompheniramine Moderate
- Brivaracetam + Dexbrompheniramine Moderate
- Cariprazine + Dexbrompheniramine Moderate
- Dexbrompheniramine + Esketamine Moderate
Frequently asked questions
Can I take Brimonidine with Dexbrompheniramine?
MediHelp rates the interaction as moderate. Brimonidine and Dexbrompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexbrompheniramine is a sedating first-generation antihistamine. Together with brimonidine, drowsiness and reduced alertness may be increased.
How serious is the interaction between Brimonidine and Dexbrompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks if drowsy. Consider a non-sedating antihistamine as an alternative.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
