Drug interactions
Brexpiprazole + Dexbrompheniramine
Severity: Moderate
Brexpiprazole and Dexbrompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so taking them together can deepen drowsiness and impair alertness, psychomotor performance and driving ability. The effect is most relevant in older patients and at treatment initiation.
What this interaction means in plain words
Brexpiprazole and Dexbrompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Dexbrompheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from antihistaminergic and antipsychotic sedative effects.
What to do
Warn patients about drowsiness and avoid driving or hazardous tasks until response is known. Prefer a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Dexbrompheniramine
- Amisulpride + Dexbrompheniramine Moderate
- Asenapine + Dexbrompheniramine Moderate
- Brimonidine + Dexbrompheniramine Moderate
- Brivaracetam + Dexbrompheniramine Moderate
- Cariprazine + Dexbrompheniramine Moderate
- Dexbrompheniramine + Esketamine Moderate
Frequently asked questions
Can I take Brexpiprazole with Dexbrompheniramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Dexbrompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so taking them together can deepen drowsiness and impair alertness, psychomotor performance and driving ability. The effect is most relevant in older patients and at treatment initiation.
How serious is the interaction between Brexpiprazole and Dexbrompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and avoid driving or hazardous tasks until response is known. Prefer a non-sedating antihistamine if one is needed.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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