Drug interactions
Dexbrompheniramine + Fentanyl
Severity: Moderate
Dexbrompheniramine and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexbrompheniramine is a sedating antihistamine that adds to fentanyl's CNS depression. The combination can cause marked drowsiness and impaired psychomotor function, and respiratory depression is possible with higher doses.
What this interaction means in plain words
Dexbrompheniramine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexbrompheniramine belongs to Respiratory; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS depression from an opioid and a sedating first-generation antihistamine.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Advise patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Dexbrompheniramine
- Amisulpride + Dexbrompheniramine Moderate
- Asenapine + Dexbrompheniramine Moderate
- Brexpiprazole + Dexbrompheniramine Moderate
- Brimonidine + Dexbrompheniramine Moderate
- Brivaracetam + Dexbrompheniramine Moderate
- Cariprazine + Dexbrompheniramine Moderate
Frequently asked questions
Can I take Dexbrompheniramine with Fentanyl?
MediHelp rates the interaction as moderate. Dexbrompheniramine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexbrompheniramine is a sedating antihistamine that adds to fentanyl's CNS depression. The combination can cause marked drowsiness and impaired psychomotor function, and respiratory depression is possible with higher doses.
How serious is the interaction between Dexbrompheniramine and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Advise patients to avoid alcohol and driving.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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