Drug interactions
Dexchlorpheniramine + Dextroamphetamine
Severity: Minor
Dexchlorpheniramine and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine and dextroamphetamine a stimulant, so they have opposing effects on alertness. The stimulant may mask drowsiness. Clinical consequences are generally small.
What this interaction means in plain words
Dexchlorpheniramine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexchlorpheniramine belongs to Respiratory; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing CNS pharmacodynamic effects.
What to do
Monitor for sedation and for any reduced antihistamine or stimulant effect. No dose adjustment is routinely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Dextroamphetamine?
MediHelp rates the interaction as minor. Dexchlorpheniramine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexchlorpheniramine is a sedating antihistamine and dextroamphetamine a stimulant, so they have opposing effects on alertness. The stimulant may mask drowsiness. Clinical consequences are generally small.
How serious is the interaction between Dexchlorpheniramine and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for any reduced antihistamine or stimulant effect. No dose adjustment is routinely required.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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