Drug interactions
Dexfenfluramine + Haloperidol
Severity: Minor
Dexfenfluramine and Haloperidol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonin-releasing agent that was withdrawn from the market, and its interaction with haloperidol is poorly defined. Opposing effects on sedation are possible, and serotonergic agents combined with antipsychotics could theoretically raise the risk of serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Dexfenfluramine and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects; no established pharmacokinetic mechanism.
What to do
Dexfenfluramine is not generally available; if encountered, monitor mental status and neuromuscular signs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Haloperidol?
MediHelp rates the interaction as minor. Dexfenfluramine and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexfenfluramine is a serotonin-releasing agent that was withdrawn from the market, and its interaction with haloperidol is poorly defined. Opposing effects on sedation are possible, and serotonergic agents combined with antipsychotics could theoretically raise the risk of serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Dexfenfluramine and Haloperidol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dexfenfluramine is not generally available; if encountered, monitor mental status and neuromuscular signs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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