Drug interactions
Dexfenfluramine + Insulin glargine
Severity: Moderate
Dexfenfluramine and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine may increase peripheral glucose uptake and reduce appetite, increasing the risk of hypoglycemia with insulin. Insulin needs may fall during treatment.
What this interaction means in plain words
Dexfenfluramine and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enhanced peripheral glucose uptake and reduced food intake adds to the glucose-lowering effect of insulin.
What to do
Monitor blood glucose closely and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Dexfenfluramine with Insulin glargine?
MediHelp rates the interaction as moderate. Dexfenfluramine and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine may increase peripheral glucose uptake and reduce appetite, increasing the risk of hypoglycemia with insulin. Insulin needs may fall during treatment.
How serious is the interaction between Dexfenfluramine and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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