Drug interactions
Dexfenfluramine + Pentazocine
Severity: Moderate
Dexfenfluramine and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine releases serotonin and blocks its reuptake, so combining it with pentazocine may raise the risk of serotonin syndrome. The drug has been withdrawn in most markets, so the combination is rarely encountered.
What this interaction means in plain words
Dexfenfluramine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonin release and reuptake inhibition by dexfenfluramine, possibly added to weak serotonergic effects of pentazocine.
What to do
Avoid the combination where possible and monitor for agitation, tremor, hyperreflexia and hyperthermia. Stop the serotonergic agent if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Dexfenfluramine with Pentazocine?
MediHelp rates the interaction as moderate. Dexfenfluramine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine releases serotonin and blocks its reuptake, so combining it with pentazocine may raise the risk of serotonin syndrome. The drug has been withdrawn in most markets, so the combination is rarely encountered.
How serious is the interaction between Dexfenfluramine and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and monitor for agitation, tremor, hyperreflexia and hyperthermia. Stop the serotonergic agent if toxicity appears.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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