Drug interactions
Dexfenfluramine + Promethazine
Severity: Minor
Dexfenfluramine and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a withdrawn serotonergic anorectic with no established significant interaction with promethazine. Theoretical effects include opposing CNS actions and additive cardiac effects.
What this interaction means in plain words
Dexfenfluramine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not established; possible opposing CNS effects.
What to do
No specific action is needed beyond monitoring sedation and heart rhythm in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Dexfenfluramine with Promethazine?
MediHelp rates the interaction as minor. Dexfenfluramine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexfenfluramine is a withdrawn serotonergic anorectic with no established significant interaction with promethazine. Theoretical effects include opposing CNS actions and additive cardiac effects.
How serious is the interaction between Dexfenfluramine and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring sedation and heart rhythm in at-risk patients.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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