Drug interactions
Dexlansoprazole + Drospirenone
Severity: Minor
Dexlansoprazole and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has minimal CYP3A4 inhibitory activity at clinical doses, so a relevant increase in dexlansoprazole exposure is unlikely.
What this interaction means in plain words
Dexlansoprazole and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Drospirenone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 inhibition; not established clinically.
What to do
No dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Dexlansoprazole with Drospirenone?
MediHelp rates the interaction as minor. Dexlansoprazole and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has minimal CYP3A4 inhibitory activity at clinical doses, so a relevant increase in dexlansoprazole exposure is unlikely.
How serious is the interaction between Dexlansoprazole and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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