Drug interactions
Dexlansoprazole + Iron
Severity: Moderate
Dexlansoprazole and Iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Proton pump inhibitors reduce absorption of oral non-heme iron, and long-term use is associated with iron deficiency or poor response to supplements. This is most relevant in patients who depend on oral iron.
What this interaction means in plain words
Dexlansoprazole and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Iron belongs to Gastrointestinal Tract.
Why it happens
Profound acid suppression raises gastric pH, limiting iron solubility and reduction to the ferrous form.
What to do
Monitor hemoglobin and ferritin, and consider intravenous iron or the lowest effective PPI dose if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Iron?
MediHelp rates the interaction as moderate. Dexlansoprazole and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Proton pump inhibitors reduce absorption of oral non-heme iron, and long-term use is associated with iron deficiency or poor response to supplements. This is most relevant in patients who depend on oral iron.
How serious is the interaction between Dexlansoprazole and Iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin, and consider intravenous iron or the lowest effective PPI dose if response is poor.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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