Drug interactions
Dexlansoprazole + Pazopanib
Severity: Major
Dexlansoprazole and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on an acidic gastric environment, and dexlansoprazole produces prolonged acid suppression. Exposure to pazopanib can fall, which may reduce antitumour efficacy.
What this interaction means in plain words
Dexlansoprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexlansoprazole belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Raised gastric pH reduces the pH-dependent solubility and absorption of oral pazopanib.
What to do
Avoid concurrent PPI use where possible; if acid suppression is needed, use a short-acting antacid separated from pazopanib by several hours. If a PPI is unavoidable, pazopanib should be taken once daily in the evening together with the PPI, per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Dexlansoprazole with Pazopanib?
MediHelp rates the interaction as major. Dexlansoprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib absorption depends on an acidic gastric environment, and dexlansoprazole produces prolonged acid suppression. Exposure to pazopanib can fall, which may reduce antitumour efficacy.
How serious is the interaction between Dexlansoprazole and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent PPI use where possible; if acid suppression is needed, use a short-acting antacid separated from pazopanib by several hours. If a PPI is unavoidable, pazopanib should be taken once daily in the evening together with the PPI, per labeling.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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