Drug interactions
Dexlansoprazole + Risedronate
Severity: Minor
Dexlansoprazole and Risedronate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delayed-release risedronate formulations contain a pH-sensitive coating, and higher gastric pH can cause earlier release and greater absorption. Separately, long-term PPI use is linked to fracture risk, which is relevant in osteoporosis patients.
What this interaction means in plain words
Dexlansoprazole and Risedronate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Risedronate belongs to Musculoskeletal.
Why it happens
Elevated gastric pH alters release from pH-dependent delayed-release risedronate, increasing absorption.
What to do
Use the immediate-release formulation or review the need for the PPI; no dose change is typically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Risedronate
- Aluminum hydroxide + Risedronate Moderate
- Calcium acetate + Risedronate Moderate
- Calcium carbonate + Risedronate Moderate
- Calcium chloride + Risedronate Moderate
- Calcium citrate + Risedronate Moderate
- Calcium gluconate + Risedronate Moderate
Frequently asked questions
Can I take Dexlansoprazole with Risedronate?
MediHelp rates the interaction as minor. Dexlansoprazole and Risedronate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Delayed-release risedronate formulations contain a pH-sensitive coating, and higher gastric pH can cause earlier release and greater absorption. Separately, long-term PPI use is linked to fracture risk, which is relevant in osteoporosis patients.
How serious is the interaction between Dexlansoprazole and Risedronate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the immediate-release formulation or review the need for the PPI; no dose change is typically needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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