Drug interactions
Dexlansoprazole + Sotorasib
Severity: Moderate
Dexlansoprazole and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib has pH-dependent solubility, and PPIs lower its exposure. This may decrease antitumor efficacy.
What this interaction means in plain words
Dexlansoprazole and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Increased gastric pH reduces sotorasib solubility and absorption.
What to do
Avoid PPIs where possible. If acid reduction is needed, give sotorasib 4 hours before or 10 hours after a local antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Dexlansoprazole with Sotorasib?
MediHelp rates the interaction as moderate. Dexlansoprazole and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib has pH-dependent solubility, and PPIs lower its exposure. This may decrease antitumor efficacy.
How serious is the interaction between Dexlansoprazole and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs where possible. If acid reduction is needed, give sotorasib 4 hours before or 10 hours after a local antacid.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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