Drug interactions
Dexmedetomidine + Papaveretum
Severity: Moderate
Dexmedetomidine and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opium alkaloid mixture containing morphine. With dexmedetomidine it can produce additive sedation and respiratory depression, with a risk of hypotension and bradycardia.
What this interaction means in plain words
Dexmedetomidine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and alpha-2 agonism.
What to do
Reduce initial doses and monitor respiratory rate, oxygen saturation and sedation depth. Titrate each drug to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Papaveretum?
MediHelp rates the interaction as moderate. Dexmedetomidine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum is an opium alkaloid mixture containing morphine. With dexmedetomidine it can produce additive sedation and respiratory depression, with a risk of hypotension and bradycardia.
How serious is the interaction between Dexmedetomidine and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce initial doses and monitor respiratory rate, oxygen saturation and sedation depth. Titrate each drug to effect.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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