Drug interactions
Dexmedetomidine + Triclofos
Severity: Moderate
Dexmedetomidine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and with dexmedetomidine it can produce excessive sedation. Respiratory depression and hemodynamic effects may be more pronounced, especially in children and elderly patients.
What this interaction means in plain words
Dexmedetomidine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from alpha-2 agonism combined with GABAergic sedative-hypnotic activity of trichloroethanol.
What to do
Use lower doses of dexmedetomidine and monitor sedation level, oxygen saturation and respiratory rate. Have airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexmedetomidine and Triclofos, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Triclofos?
MediHelp rates the interaction as moderate. Dexmedetomidine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and with dexmedetomidine it can produce excessive sedation. Respiratory depression and hemodynamic effects may be more pronounced, especially in children and elderly patients.
How serious is the interaction between Dexmedetomidine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower doses of dexmedetomidine and monitor sedation level, oxygen saturation and respiratory rate. Have airway support available.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
