Drug interactions
Dexmedetomidine + Yohimbine
Severity: Moderate
Dexmedetomidine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist and can oppose the sedative, sympatholytic and hemodynamic effects of dexmedetomidine. The result may be reduced sedation, tachycardia or hypertension.
What this interaction means in plain words
Dexmedetomidine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at alpha-2 adrenergic receptors.
What to do
Avoid combining where possible, or be prepared to increase the dexmedetomidine dose. Monitor sedation, heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Yohimbine?
MediHelp rates the interaction as moderate. Dexmedetomidine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist and can oppose the sedative, sympatholytic and hemodynamic effects of dexmedetomidine. The result may be reduced sedation, tachycardia or hypertension.
How serious is the interaction between Dexmedetomidine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or be prepared to increase the dexmedetomidine dose. Monitor sedation, heart rate and blood pressure.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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