Drug interactions
Dexrazoxane + Zidovudine
Severity: Moderate
Dexrazoxane and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexrazoxane can cause myelosuppression, and zidovudine commonly causes anemia and neutropenia. Combined use may worsen blood count suppression.
What this interaction means in plain words
Dexrazoxane and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexrazoxane belongs to Miscellaneous; Zidovudine belongs to Anti Virals.
Why it happens
Additive bone marrow suppression.
What to do
Monitor complete blood counts regularly during coadministration. Adjust doses or hold therapy if significant cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Dexrazoxane
- Dexrazoxane + Hydroxycarbamide Moderate
- Dexrazoxane + Lomustine Moderate
Frequently asked questions
Can I take Dexrazoxane with Zidovudine?
MediHelp rates the interaction as moderate. Dexrazoxane and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexrazoxane can cause myelosuppression, and zidovudine commonly causes anemia and neutropenia. Combined use may worsen blood count suppression.
How serious is the interaction between Dexrazoxane and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly during coadministration. Adjust doses or hold therapy if significant cytopenias occur.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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